After an apprenticeship as a bookseller, Erhard Weyhe emigrated to the United States in 1914 and opened his bookstore in 1919. In the mid-1930s, the store developed into a renowned art bookstore, which also presented small exhibitions on the second floor. The art historian Carl Zigrosser was the gallery's first manager. It was located on 794 Lexington Avenue and not far away of the 57th streets, where the other galleries as the Norlyst Gallery or the Julien Levy Gallery were placed.

In addition to exhibiting prints, during the 1930s and 1940s the Weyhe Gallery also hosted a number of photographic exhibitions. The gallery also supported the work of émigré photographers, where the research is quite understudied.

Photographic works by Berenice Abbot were shown at the gallery on 24 November 1930 and work by the photographer Eugene Atget was also shown the same year (Morris 1930, 69). In 1938, works by the émigré photographer Ruth Bernhard were shown and, in February 1942, images by the animal photographer Ylla were exhibited. Ylla also participated in an exhibition on the topic of cats in November 1942. How important the Wehye Gallery was for émigré photographers during the 1930s and 1940s and whether it acted as a network hub for them has not been sufficiently studied.